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Free Control leptin and you will control body fat loss Airmont

Published date: May 6, 2020
  • Location: Airmont, New York, United States

First of all it is important to understand that fat is not simply a reserve tank for excess calories or "potential energy." Fat is an endocrine organ, such as the thyroid or adrenal glands, for example. This means that fat, in this case white adipose tissue secretes hormones and leptin is one of them. Leptin is a polypeptide hormone (made up of 146 amino acids) produced by adipocytes (fat cells). The more fat the adipocytes contain, the more leptin is secreted. Think of leptin as a metabolism controller and a hunger regulator.  It links changes in fat deposits with the control of CNS energy homeostasis.

How do we become resistant to leptin?

Reduction of the blood-brain barrier:  The idea that leptin levels were higher in obese people was a surprise. When scientists tested the responsiveness to leptin of various animal tissues resistant to it, in vitro. Most of the time, leptin receptors isolated from the hypothalamus were still somewhat sensitive. This was a huge puzzle until it was discovered that part of the body's response to high levels of leptin is to shut off brain access to it. In order for leptin to get from fat cells to the hypothalamus, leptin must travel through the bloodstream, but it has to cross the brain's blood-brain barrier to gain access. The blood-brain barrier is highly selective in what it allows to pass through it, and it was found that an early response to high levels of leptin closes off the passage through the blood-brain barrier. This allows the body to preserve leptin sensitivity in the hypothalamus whenever it can, spreading until leptin levels return to normal again.

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